Thrombophilia – Thrombocytopenia What is it?

Thrombophilia Thrombocytopenia What is it?

The term Thrombophilia is used to describe the predisposition of some people’s body to coagulate blood.

Clot formation is the pathological condition that can occur as vascular thrombosis, complications in pregnancy or pulmonary embolism.

Factors that influence Thrombophilia and clot formation.

The factors that can influece people with Thrombophilia are:

• Heredity
• Environental
• Acquired

And also:

• Age
• Obesity
• Pregnancy
• Cancer
• Surgeries
• Venous insufficiency
• Autoimmune disorders
• Inflammatory diseases
• Use of venous catheters
• Long term immobility
• Use of certain drugs
• Cardiac disorders

Thrombophilia and Covid-19 (coronavirus)

Patients with symptoms suspected of thrombosis after vaccination against the Covid-19 infection must undergo a series of tests necessary for proper diagnosis and treatment. Because early diagnosis and appropriate treatment are vital.

What tests should I do to check if I have thrombophilia?

The preventive tests for thrombophilia include:

Biochemical and genetic factors.

Laboratory testing includes examination of all mutations for hereditary thrombophilia and some factors related to acquired thrombophilia. In the case of pregnancy, it is good to have continuous monitoring with blood tests

Specifically, our laboratory tests for the following mutations and polymorphisms:

• Factor II (prothrombin mutation G20210A)
• Factor V (Leiden mutation G1691A)
• Factor V (R2 mutation, H1299R)
• Factor XIII (V34L mutation)
• β-fibrinogen (–455 G>A)
• AGT M235T angiotensinogen
• GPIIIa (HPA-1, polymorphism a/b)
• MTHFR (homocysteine mutation C677T)
• MTHFR (homocysteine mutation A1298C)
• Plasminogen activator inhibitor 1 (PAI-1 polymorphism 4G/5G)
• Angiotensin-converting enzyme (ACE, insertion/deletion polymorphism)
• Angiotensin II type 1 receptor (A1166C mutation)
• Apolipoprotein E genotyping
• Cystathionine beta-synthase (CBS)

What is thrombocytopenia? What causes Thrombocytopenia?

Thrombocytopenia is mainly due to the lack of platelets, which leads to the thinning of the blood.

Which factors contribute to Thrombocytopenia?

Factors that affect blood thinning and can lead to thrombocytopenia are also:

Ageing: Platelet numbers can decrease with age.

Genetics: Some people have a low platelet count due to genetic factors.

Εγκυμοσύνη: 5-7% of pregnant women suffer from blood thinning, due to a decrease in the number of blood platelets

How is thrombocytopenia diagnosed?

Thrombocytopenia is diagnosed with a regular complete blood count (CBC)

Does the Vaccine Cause Thrombocytopenia or Thrombophilia?

According to new studies the vaccine can cause the syndrome vaccine induced immune thrombotic thrombocytopenia –VIIT. In other words, this syndrome can cause thrombotic thrombocytopenia after vaccination.

How many days post vaccination do the symptoms of thrombocytopenia or thrombophilia appear?

The appearance of clots or thrombocytopenia can occur from 5 to 24 days and is found in vaccines that have the adenovirus as a carrier. Such vaccines are AstraZeneca, Johnson and the Russian Sputnik V. A notable observation is that post-vaccine clots were observed in unusual areas (head, liver, etc.)

Correspondingly, cases of thrombocytopenia have been observed after vaccination with mRNA Technology vaccines.

The benefits of vaccination are considered much greater than the drawbacks of the Covid-19 infection.

If I have thrombophilia or thrombocytopenia can I be exempt from the vaccine?

The reasons for exemption from the vaccine with regard to thrombophilia or thrombocytopenia are established by legislation, and exclude groups of people who:

• They developed Thrombosis with Thrombocytopenia Syndrome (TTS) after the first dose of the Astra Zeneca and Janssen/Johnson & Johnson vaccines against the coronavirus COVID-19.
• They have a history of heparininduced thrombocytopenia, or a history of antiphospholipid syndrome (APS), or capillary leak syndrome

What tests can I do to check if I have thrombophilia or thrombocytopenia and if I can get the vaccine?

Tests required are thrombophilia gene factors and CBC for Thrombocytopenia.

The procedure required is a simple blood draw.